منابع مشابه
Niche required for inducing quiescent stem cells.
Quiescence is an important feature distinguishing stem cells (SCs) from other compartments for most SC systems. Evidence suggests that the quiescent state is directed by external cues expressed in the presumptive microenvironment, the niche, although the cellular and molecular nature of the niche remains obscure in most SC systems. Our group has been addressing this question using the melanocyt...
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Hematopoietic stem cell (HSC) numbers are tightly regulated and maintained in postnatal hematopoiesis. Extensive studies have supported a role of the cytokine tyrosine kinase receptor Kit in sustaining cycling HSCs when competing with wild-type HSCs posttransplantation, but not in maintenance of quiescent HSCs in steady state adult bone marrow. In this study, we investigated HSC regulation in W...
متن کاملThe secret life of quiescent cancer stem cells
Quiescence represents a survival strategy adopted by cancer stem cells (CSCs) to resist harsh environmental conditions and cytotoxic insults. Recent studies show that quiescent CSCs are found in a low metabolic state in which they are exquisitely dependent on Bcl-2 or Bcl-XL, indicating new potential routes of clinical intervention.
متن کاملCoexistence of quiescent and active adult stem cells in mammals.
Adult stem cells are crucial for physiological tissue renewal and regeneration after injury. Prevailing models assume the existence of a single quiescent population of stem cells residing in a specialized niche of a given tissue. Emerging evidence indicates that both quiescent (out of cell cycle and in a lower metabolic state) and active (in cell cycle and not able to retain DNA labels) stem ce...
متن کاملQuiescent gastric stem cells maintain the adult Drosophila stomach.
The adult Drosophila copper cell region or "stomach" is a highly acidic compartment of the midgut with pH < 3. In this region, a specialized group of acid-secreting cells similar to mammalian gastric parietal cells has been identified by a unique ultrastructure and by copper-metallothionein fluorescence. However, the homeostatic mechanism maintaining the acid-secreting "copper cells" of the adu...
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ژورنال
عنوان ژورنال: Pigment Cell Research
سال: 2007
ISSN: 0893-5785,1600-0749
DOI: 10.1111/j.1600-0749.2007.00388.x